Let me explain this phrase by quoting Matthew 1:18, “This is how the birth of Jesus Christ came about: His mother Mary was pledged to be married to Joseph, but before they came together, she was found to be with child through the Holy Spirit.”
Mary had never “known” a man before; she was a virgin in the very technical sense of the word (verse 23). Jesus was conceived by the Holy Spirit without the intervention of a human father. Joseph and Mary did not have sexual intercourse until after Mary gave birth to Jesus.
Now, for a brief biology lesson! When the male sperm and female ovum (egg) unite in what we refer to as conception, it is the male seed that determines both the sex of the child and the blood type of the fetus. Therefore, when Mary conceived, it was in fact the very blood of God that began life in Mary’s womb, and that later coursed through the veins of our Lord Jesus Christ.
It was blood that was uncontaminated by sin. The blood of God bypassed the genetic code of Mary and remained untouched by sin. Jesus was the spotless Lamb of God. That’s why Paul could write in 2 Corinthians 5:21, “God made him who had no sin to be sin for us…”
The blood that Jesus shed for our redemption was the blood of God, precious blood, and atoning blood. Entire books have been written on this subject. This doctrine has been challenged, debated and ridiculed by those who try to eliminate our “crimson” salvation, but the Bible makes it clear in so many places that the blood of Jesus was truly an acceptable sacrifice for the sins of mankind.